Water → 6-(Pyrrolidin-1-yl)pyridin-2-amine
反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.C([O-])([O-])=O.[K+].[K+].[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1.O>CS(C)=O>[N:15]1([C:6]2[N:5]=[C:4]([NH2:8])[CH:3]=[CH:2][CH:7]=2)[CH2:19][CH2:18][CH2:17][CH2:16]1参加物
6
反応条件
- 温度
- 190 °C
実験手順
A mixture of 4-chloro-2-aminopyridine (19.3 g, 0.150 mol), K2CO3 (41.7 g, 0.30 mol) and pyrrolidine (32.0 g, 0.45 mol) in DMSO (150 mL) was stirred at 190° C. for 10 hours. After cooling to room temperature, water (300 mL) was added and extracted with ethyl acetate (150 mL×4). The combined organic layers were washed with water (25 mL×3), dried over Na2SO4 and concentrated in vacuo, the residue was purified by silica gel chromatography (10:1 ethyl acetate/petroleum ether) to obtain 6-(pyrrolidin-1-yl)pyridin-2-amine (9.0 g, 37% yield).
後処理
- temperatureAfter cooling to room temperature
- extractionextracted with ethyl acetate (150 mL×4)
- washThe combined organic layers were washed with water (25 mL×3)
- dry with materialdried over Na2SO4
- concentrationconcentrated in vacuo
- customthe residue was purified by silica gel chromatography (10:1 ethyl acetate/petroleum ether)
出典と根拠
- ORDレコード
- ord-ab6ebf7b1b8344fca4c699a1ad790a72
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08685970B2
反応ノート
読み込み中…