Glycidol → 3-(1-Phenyl-3-butyl)amino-1,2-propanediol
反応式
[CH2:1]1[O:3][CH:2]1[CH2:4][OH:5].[C:6]1([CH2:12][CH2:13][CH:14]([NH2:16])[CH3:15])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(O)(C)C>[C:6]1([CH2:12][CH2:13][CH:14]([NH:16][CH2:1][CH:2]([OH:3])[CH2:4][OH:5])[CH3:15])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1参加物
4
反応条件
- 温度
- 70 °C
実験手順
A solution of glycidol (11.5 g, 0.155 mol) in isopropanol (25 ml) was added dropwise under N2 at 40° C. to a solution of 1-phenyl-3-butylamine in isopropanol (50 ml). After 1 hour, the solution was heated at 70° C. for 1.5 hours and then at room temperature overnight. The isopropanol was removed under reduced pressure and the residue distilled to yield 24 g (70%) of 94; b.p.0.2 140°-5° C.
後処理
- customat room temperature
- customovernight
- customThe isopropanol was removed under reduced pressure
- distillationthe residue distilled
出典と根拠
- ORDレコード
- ord-8c87308af1624cf29f8cadda2a8146a7
- 出典データセット
- uspto-grants-1987_02
- 特許番号
- US04642311
反応ノート
読み込み中…