Acetyl chloride → N-[(6-Bromopyridin-2-yl)sulphonyl]acetamide

HRID 2359918ノート

反応式

HRID 2359918 の反応式
[Br:1][C:2]1[N:7]=[C:6]([S:8]([NH2:11])(=[O:10])=[O:9])[CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[C:18](Cl)(=[O:20])[CH3:19]>C(#N)C>[Br:1][C:2]1[N:7]=[C:6]([S:8]([NH:11][C:18](=[O:20])[CH3:19])(=[O:9])=[O:10])[CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 11430Potassium CarbonateHCID 573458166-Bromopyridine-2-sulfonamide

生成物 1

HCID 86667250N-[(6-Bromopyridin-2-yl)sulphonyl]acetamide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

6-Bromopyridine-2-sulphonamide (0.5 g, 2.11 mmol, prepared by the methods described in WO2005/058299) and potassium carbonate (2.92 g, 21.1 mmol) were initially charged in acetonitrile (10 ml). While cooling with ice, acetyl chloride (1.16 g, 14.8 mmol) was added dropwise and the reaction mixture was stirred at room temperature for 16 h. The solvent was removed under reduced pressure, and the residue was taken up in water and acidified with dilute hydrochloric acid solution. It was extracted with ethyl acetate and the solvent was removed under reduced pressure. This gave 0.54 g (85% of theory) of N-[(6-bromopyridin-2-yl)sulphonyl]-acetamide.

後処理

  1. additionwas added dropwise
  2. customThe solvent was removed under reduced pressure
  3. extractionIt was extracted with ethyl acetate
  4. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-e4177b39fa5f40ca9af2143ba7806818
出典データセット
uspto-grants-2014_04
特許番号
US08686004B2

反応ノート

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