Acetone Cyanohydrin → 1-Benzyl-5,5-diethyl-2,2-dimethyl-piperazine

反応式

[CH2:1](N1CC(C)(C)NCC21CCCC2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:20][CH2:21][C:22]([NH2:27])([CH2:25][CH3:26])[CH2:23][CH3:24].[CH3:28][C:29]([CH3:33])(O)[C:30]#N>>[CH2:1]([N:20]1[CH2:21][C:22]([CH2:25][CH3:26])([CH2:23][CH3:24])[NH:27][CH2:28][C:29]1([CH3:33])[CH3:30])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

反応物 3

HCID 6406Acetone Cyanohydrin

HCID 432996Diethylethylene diamine

HCID 64842474HCID 64842474、化合物

生成物 1

HCID 648606481-Benzyl-5,5-diethyl-2,2-dimethyl-piperazine

実験手順

1-Benzyl-5,5-diethyl-2,2-dimethyl-piperazine was synthesized in analogy to 6-benzyl-8,8-dimethyl-6,9-diaza-spiro[4.5]decane starting from 3-(aminomethyl)pentane-3-amine and acetone cyanohydrin.

出典と根拠

ORDレコード: ord-3272d54eb80d47efa253f6baa4ebd1e5
出典データセット: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08686150B2

反応ノート

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