9-Nitro-5,6-dihydro-benzo[f]quinoline → 9-Amino-5,6-dihydro-benzo[f]quinoline

HRID 2360773ノート

反応式

HRID 2360773 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[CH2:16][CH2:15][C:14]3[N:13]=[CH:12][CH:11]=[CH:10][C:9]=3[C:8]=2[CH:17]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[CH2:16][CH2:15][C:14]3[N:13]=[CH:12][CH:11]=[CH:10][C:9]=3[C:8]=2[CH:17]=1

参加物

4

反応物 1

HCID 582946079-Nitro-5,6-dihydro-benzo[f]quinoline

生成物 1

HCID 582945549-Amino-5,6-dihydro-benzo[f]quinoline

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 9-nitro-5,6-dihydro-benzo[f]quinoline (1.90 g), 10% palladium on carbon (0.20 g), and methanol (10 mL) is shaken under hydrogen atmosphere (3 bar) at room temperature for 3 h. The catalyst is then separated by filtration and the filtrate is concentrated to give an oil that is submitted to the next reaction without further purification. Yield: 1.67 g (crude); Mass spectrum (ESI+): m/z=197 [M+H]+.

後処理

  1. customThe catalyst is then separated by filtration
  2. concentrationthe filtrate is concentrated
  3. customto give an oil that
  4. customis submitted to the next reaction without further purification

出典と根拠

ORDレコード
ord-a7c267faaaa14b33b67f1c4138b464b3
出典データセット
uspto-grants-2014_04
特許番号
US08686149B2

反応ノート

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