Diethanolamine → HCID 22590162、化合物

HRID 23612

反応式

HRID 23612 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1F)[C:6]#[N:7].[NH:14]([CH2:18][CH2:19][OH:20])[CH2:15][CH2:16][OH:17]>CN(C)C(=O)C>[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[N:14]([CH2:18][CH2:19][OH:20])[CH2:15][CH2:16][OH:17])[C:6]#[N:7]

参加物

4

反応物 2

HCID 8113DiethanolamineHCID 1442554-Fluoro-3-(trifluoromethyl)benzonitrile

生成物 1

HCID 22590162HCID 22590162、化合物

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

A solution of 3-trifluoromethyl 4-fluoro-benzonitrile (9.45 g, 50 mmol) and diethanolamine (15.8 g, 0.15 mol) in N,N-dimethylacetamide (200 ml) was stirred for 7 days at 50° C. The solvent was evaporated, the residue partitioned between CH2Cl2 (400 ml) and H2O (400 ml), the organic layer dried (MgSO4) and evaporated to dryness. The residue was chromatographed using CH2Cl2-EtOH as eluent.

後処理

  1. customThe solvent was evaporated
  2. customthe residue partitioned between CH2Cl2 (400 ml) and H2O (400 ml)
  3. dry with materialthe organic layer dried (MgSO4)
  4. customevaporated to dryness
  5. customThe residue was chromatographed

出典と根拠

ORDレコード
ord-02ab42cfd43b416bbf1faed23df2983f
出典データセット
uspto-grants-2005_02
特許番号
US06852755B1

関連ノート

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