D-Tartaric acid → L-Malic Acid

HRID 236120

反応式

HRID 236120 の反応式
[C@@H:1]([OH:10])([C:7]([OH:9])=[O:8])[C@H:2](O)[C:3]([OH:5])=[O:4]>CO>[C:7]([OH:9])(=[O:8])[C@H:1]([CH2:2][C:3]([OH:5])=[O:4])[OH:10]

参加物

3

反応物 1

HCID 439655D-Tartaric acid

生成物 1

HCID 222656L-Malic Acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

One of the intermediates, (S)-1-methyl-3-pyrrolidinol, was synthetized with retention of optical purity as shown in Chart IX starting with (S)-malic acid. The (S)-1-methyl-3-pyrrolidinol was shown to be dextrorotatory. As an alternative method of obtaining the resolved isomers of 1-methyl-3-pyrrolidinol, the racemic mixture was treated with (2S,3S)-tartaric acid in methanol. The resulting crystals, after one recrystallization, were converted to the base. This base was the dextrorotatory (S)-1-methyl-3-pyrrolidinol identical to that produced from (S)-malic acid.

後処理

  1. customThe resulting crystals, after one recrystallization

出典と根拠

ORDレコード
ord-17438ff4c7274d52954629cf58d0df8e
出典データセット
uspto-grants-1987_02
特許番号
US04642343

関連ノート

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