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HRID 2361491作成日：2026年10月27日

2-Bromo-4-nitroquinoline → N,N-dimethyl-5-(4-nitroquinolin-2-yl)pyridin-2-amine

https://huagongshe.com/reaction/2361491

反応式

関与物質

役割名称HCID仕込み量
反応物2-Bromo-4-nitroquinolineHCID 581266—
反応物6-(Dimethylamino)pyridine-3-boronic acidHCID 2763271—
生成物N,N-dimethyl-5-(4-nitroquinolin-2-yl)pyridin-2-amineHCID 58362513—

反応手順

N,N-Dimethyl-5-(4-nitroquinolin-2-yl)pyridin-2-amine T480P was prepared using general procedure A from 2-Bromo-4-nitroquinoline (50 mg, 0.2 mmol) and (6-(dimethylamino)pyridin-3-yl)boronic acid (34 mg, 0.2 mmol). The product was obtained as a yellow solid (40 mg, 68%). 1H NMR (400 MHz, CDCl3): δ 8.99 (d, J=2.4 Hz, 1H), 8.36-8.34 (m, 2H), 8.30 (s, 1H), 8.19 (m, 1H), 7.81 (m, 1H), 7.65 (m, 1H), 6.66 (d, J=9.0 Hz, 1H), 3.21 (s, 6H); MS (ESI): 295 (M+H+).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08691187B2
出典データセットuspto-grants-2014_04
ORD IDord-973335e3efa44358ba62097aa0224b53
出典メモuspto-grants-2014_04