Trifluoroacetic acid → HCID 58362692、化合物
反応式
[N:1]([CH2:4][CH2:5][CH2:6][N:7]([C:15]1[CH:20]=[CH:19][C:18]([C:21]2[N:26]3[C:27]4[CH:33]=[CH:32][CH:31]=[CH:30][C:28]=4[N:29]=[C:25]3[N:24]=[CH:23][CH:22]=2)=[CH:17][CH:16]=1)C(=O)OC(C)(C)C)=[N+:2]=[N-:3].C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:1]([CH2:4][CH2:5][CH2:6][NH:7][C:15]1[CH:16]=[CH:17][C:18]([C:21]2[N:26]3[C:27]4[CH:33]=[CH:32][CH:31]=[CH:30][C:28]=4[N:29]=[C:25]3[N:24]=[CH:23][CH:22]=2)=[CH:19][CH:20]=1)=[N+:2]=[N-:3]参加物
4
実験手順
To a solution of tert-butyl (3-azidopropyl)(4-(benzo[4,5]imidazo[1,2-a]pyrimidin-4-yl)phenyl)carbamate (above mentioned material) in 3 mL of DCM was added TFA (1 mL). The mixture was stirred at rt for 1.5 h and concentrated under reduced pressure. The residue was purified by reversed phase HPLC (TFA buffered water/MeCN) to afford the title compound as a orange-colored oil (61 mg, TFA salt). MS (ESI) m/z [M-1-H]+344.