Acetic Anhydride → HCID 12896718、化合物

HRID 2361627ノート

反応式

HRID 2361627 の反応式
[C@@H:1]1([N:10]2[CH:15]=[CH:14][C:13](=[O:16])[NH:12][C:11]2=[O:17])[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@@H:2]1[OH:3].C(O[C:22](=[O:24])[CH3:23])(=O)C>N1C=CC=CC=1>[C:2]([O:3][C@H:2]1[C@H:4]([O:5][C:4](=[O:5])[CH3:6])[C@@H:6]([CH2:8][O:9][C:22](=[O:24])[CH3:23])[O:7][C@H:1]1[N:10]1[CH:15]=[CH:14][C:13](=[O:16])[NH:12][C:11]1=[O:17])(=[O:3])[CH3:1]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 18323Uracil Arabinoside

生成物 1

HCID 12896718HCID 12896718、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

500 mg (2.05 mmol) of the above product 3 is taken as the starting material, and dissolved in 35 mL of pyridine. Then 11 ml of acetic anhydride is added with continuously stirring. The solution is concentrated under reduced pressure by removing the residual part of the solution after the completion of the reaction, and then purified by rapid column chromatography (acetone/n-hexane=4:5). A white product (1-(2′,3′,5′-Tri-O-acetyl-β-D-arabinofuranosyl)-pyrimidin-2,4-(3H)-dione) 4 is obtained. Its weight and yield are 675 mg and 89% respectively.

後処理

  1. concentrationThe solution is concentrated under reduced pressure
  2. customby removing the residual part of the solution
  3. customafter the completion of the reaction
  4. custompurified by rapid column chromatography (acetone/n-hexane=4:5)

出典と根拠

ORDレコード
ord-19a103e640fc4e2f93ba7714bc8c86ab
出典データセット
uspto-grants-2014_04
特許番号
US08691789B2

反応ノート

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