Methyl Methanesulfonate → 3-Amino-2-methyl-5,6-bis(4-methylphenyl)-1,2,4-triazine mesylate

HRID 2361860ノート

反応式

HRID 2361860 の反応式
[NH2:1][C:2]1[N:3]=[N:4][C:5]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[N:7]=1.[CH3:22][S:23]([O:26]C)(=[O:25])=[O:24]>CO>[S:23]([OH:26])(=[O:25])(=[O:24])[CH3:22].[NH2:1][C:2]1[N:3]([CH3:22])[NH:4][C:5]([C:15]2[CH:16]=[CH:17][C:18]([CH3:21])=[CH:19][CH:20]=2)=[C:6]([C:8]2[CH:9]=[CH:10][C:11]([CH3:14])=[CH:12][CH:13]=2)[N:7]=1

参加物

4

反応物 2

HCID 4156Methyl MethanesulfonateHCID 581031023-Amino-5,6-bis(4-methylphenyl)-1,2,4-triazine

生成物 1

HCID 866497323-Amino-2-methyl-5,6-bis(4-methylphenyl)-1,2,4-triazine mesylate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 3-amino-5,6-bis(4-methylphenyl)-1,2,4-triazine (500 mg), methyl methanesulphonate (0.5 cm3) and methanol (10 cm3) was stirred at 40° for 24 hours and then evaporated to dryness. The resulting yellow solid was recrystallised from acetone giving the title compound as pale yellow needles,

後処理

  1. customevaporated to dryness
  2. customThe resulting yellow solid was recrystallised from acetone giving the title compound as pale yellow needles

出典と根拠

ORDレコード
ord-74a29c942b2c4c80a58efd4e91438d1d
出典データセット
uspto-grants-2014_04
特許番号
US08691818B2

反応ノート

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