(S)-N-Cbz-1,1-diethoxypropan-2-amine → (2S)-1,1-Diethoxy-2-propanamine

HRID 2361956ノート

反応式

HRID 2361956 の反応式
[CH2:1]([O:3][CH:4]([O:18][CH2:19][CH3:20])[C@@H:5]([NH:7]C(=O)OCC1C=CC=CC=1)[CH3:6])[CH3:2]>CO.[Pd]>[CH2:1]([O:3][CH:4]([O:18][CH2:19][CH3:20])[C@@H:5]([NH2:7])[CH3:6])[CH3:2]

参加物

4

反応物 1

HCID 86652567(S)-N-Cbz-1,1-diethoxypropan-2-amine

生成物 1

HCID 12398111(2S)-1,1-Diethoxy-2-propanamine収率 100.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of (S)-benzyl 1,1-diethoxypropan-2-ylcarbamate (844 mg, 3.00 mmol) in methanol (50 ml) was added 5% palladium on carbon (30 mg) and the mixture was stirred at room temperature for 2 hr under hydrogen atmosphere. The reaction mixture was filtered on Celite and washed with methanol (200 ml) and the filtrate was concentrated in vacuo to obtain the title compound (442 mg, 100%).

後処理

  1. filtrationThe reaction mixture was filtered on Celite
  2. washwashed with methanol (200 ml)
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-f099a669951f4b8aa112bc978974144a
出典データセット
uspto-grants-2014_04
特許番号
US08691819B2

反応ノート

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