Trifluoroacetic acid → 5-[4-(1-Amino-cyclobutyl)-phenyl]-6-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine

HRID 2362173ノート

反応式

HRID 2362173 の反応式
C(OC(=O)[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:23]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:22][N:21]4[N:30]=[C:31]([NH2:33])[N:32]=[C:20]4[N:19]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][C:8]1([C:12]2[CH:13]=[CH:14][C:15]([C:18]3[C:23]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:22][N:21]4[N:30]=[C:31]([NH2:33])[N:32]=[C:20]4[N:19]=3)=[CH:16][CH:17]=2)[CH2:11][CH2:10][CH2:9]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 66823557HCID 66823557、化合物

生成物 1

HCID 469274685-[4-(1-Amino-cyclobutyl)-phenyl]-6-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To the solution of 6-1 (46 mg, 0.1 mmol) in 1 mL of DCM was added TFA (1 mL) and the mixture was stirred at room temperature for 3 h. The mixture was concentrated by evaporation and the residue was purified by prep.HPLC to give the product 6-2.

後処理

  1. concentrationThe mixture was concentrated by evaporation
  2. customthe residue was purified by prep.HPLC

出典と根拠

ORDレコード
ord-58cbce74fd2b4abfab343c9d54b3689f
出典データセット
uspto-grants-2014_04
特許番号
US08691825B2

反応ノート

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