Hydrogen Peroxide → 5-Aminopyridine-2-carboxamide
反応式
[OH:1]O.[OH-].[Na+].[NH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]#[N:13])=[N:10][CH:11]=1>CO>[NH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]([NH2:13])=[O:1])=[N:10][CH:11]=1参加物
5
実験手順
A 18 ml vial was loaded with a mixture of 30% H2O2 (1 ml), 3N NaOH (3 ml) and MeOH (2.5 ml). To this mixture 5-Amino-pyridine-2-carbonitrile (450 mg, 3.78 mmole) was added at room temperature. Reaction mixture was stirred at rt for 45 minutes, TLC showed the starting material to be consumed. The mixture was diluted with water and filtered; the solid was washed with water and dried to give 480 mg product, 92% yield.
後処理
- customReaction mixture
- customto be consumed
- additionThe mixture was diluted with water
- filtrationfiltered
- washthe solid was washed with water
- customdried
出典と根拠
- ORDレコード
- ord-14585d26549942dab63cc5daff13439d
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08691816B2
反応ノート
読み込み中…