Sodium → HCID 13770583、化合物

HRID 236227ノート

反応式

HRID 236227 の反応式
[Na].Cl[CH2:3][CH2:4][CH:5]([CH3:20])[C:6]([NH:8][C:9]1[S:10][CH:11]=[C:12]([C:16]([CH3:19])([CH3:18])[CH3:17])[C:13]=1[C:14]#[N:15])=[O:7]>C(O)C>[C:14]([C:13]1[C:12]([C:16]([CH3:19])([CH3:18])[CH3:17])=[CH:11][S:10][C:9]=1[N:8]1[CH2:3][CH2:4][CH:5]([CH3:20])[C:6]1=[O:7])#[N:15]

参加物

4

反応物 2

HCID 5360545SodiumHCID 13770589HCID 13770589、化合物

生成物 1

HCID 13770583HCID 13770583、化合物収率 75%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

To a solution of 0.21 g of sodium dissolved in 10 ml of ethanol was added 2.75 g of 4-chloro-N-[3-cyano-4-(1,1-dimethylethyl)-2-thienyl]-2-methylbutanamide dissolved in 35 ml ethanol dropwise. The mixture was allowed to stir at room temperature for about one hour and the solvent was removed in vacuo. The residue was combined with 10 ml ethanol and 250 ml water and the precipitate was collected by filtration. The collected solid was recrystallized from hexane to afford 1.8 g of N-[3-cyano-4-(1,1-dimethylethyl)-2-thienyl]-3-methyl-2-pyrrolidinone. Yield 75%. mp=92°-94° C.

後処理

  1. customthe solvent was removed in vacuo
  2. filtrationthe precipitate was collected by filtration
  3. customThe collected solid was recrystallized from hexane

出典と根拠

ORDレコード
ord-df30eafc0ee543eb824b4181757cfbd0
出典データセット
uspto-grants-1987_02
特許番号
US04643758

反応ノート

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