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2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → 1-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanamine

HRID 2362731
ノート
印刷プレビュー

反応式

HRID 2362731 の反応式
[Cl:1][C:2]1[C:3]([C:27]2[S:31][C:30]([C:32]3([NH:36]CC4C=CC(OC)=CC=4)[CH2:35][CH2:34][CH2:33]3)=[N:29][CH:28]=2)=[C:4]2[CH:10]=[C:9]([C:11]3[CH:12]=[N:13][N:14]([CH3:16])[CH:15]=3)[N:8]([S:17]([C:20]3[CH:26]=[CH:25][C:23]([CH3:24])=[CH:22][CH:21]=3)(=[O:19])=[O:18])[C:5]2=[N:6][CH:7]=1.ClC1C(=O)C(C#N)=C(C#N)C(=O)C=1Cl>ClCCl.O>[Cl:1][C:2]1[C:3]([C:27]2[S:31][C:30]([C:32]3([NH2:36])[CH2:33][CH2:34][CH2:35]3)=[N:29][CH:28]=2)=[C:4]2[CH:10]=[C:9]([C:11]3[CH:12]=[N:13][N:14]([CH3:16])[CH:15]=3)[N:8]([S:17]([C:20]3[CH:26]=[CH:25][C:23]([CH3:24])=[CH:22][CH:21]=3)(=[O:19])=[O:18])[C:5]2=[N:6][CH:7]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 67752,3-Dichloro-5,6-dicyano-1,4-benzoquinone2 回HCID 670035991-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)-N-(4-methoxybenzyl)cyclobutanamine

生成物 1

HCID 670037141-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanamine

試薬・触媒・溶媒 2

HCID 962Water溶媒
HCID 6344
Dichloromethane
溶媒

実験手順

A solution of 1-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)-N-(4-methoxybenzyl)cyclobutanamine (500 mg, 0.758 mmol) (Example 112D) in anhydrous dichloromethane (20 mL) and water (1.0 mL) was treated with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (224 mg, 0.986 mmol) and stirred for 20 minutes at ambient temperature. Additional 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (50 mg, 0.220 mmol) was added to the mixture, and the reaction stirred one hour at ambient temperature. The reaction was quenched with saturated sodium bicarbonate, and layers were separated. The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel, eluting with a gradient of 100% ethyl acetate to 5% methanol in ethyl acetate, to provide the title compound. MS ESI(+) m/z 539.1 [M+H]+.

後処理

  1. stirringthe reaction stirred one hour at ambient temperature
  2. customThe reaction was quenched with saturated sodium bicarbonate, and layers
  3. customwere separated
  4. washThe organic layer was washed with brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure
  8. customThe residue was purified by flash chromatography on silica gel
  9. washeluting with a gradient of 100% ethyl acetate to 5% methanol in ethyl acetate

出典と根拠

ORDレコード
ord-fa3c01d2019e49c8b03d6b3383f722ce
出典データセット
uspto-grants-2014_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08691810B2

反応ノート

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