C(O)C.C(=O)([O-])[O-].[Na+].[Na+].[N+:10]([C:13]1[CH:14]=[C:15]([CH:24]=[CH:25][CH:26]=1)[CH:16]=[CH:17][CH:18]=[N:19][NH:20][C:21]([NH2:23])=[S:22])([O-])=O>[H][H].[S]>[NH2:10][C:13]1[CH:14]=[C:15]([CH:24]=[CH:25][CH:26]=1)[CH:16]=[CH:17][CH:18]=[N:19][NH:20][C:21]([NH2:23])=[S:22]A solution of 10 mL ethanol and 2 mL sodium carbonate 2N is saturated in hydrogen sulfur. 500 mg (2 mmoles) 3-nitrocinnamaldehyde thiosemicarbazone prepared in step 2A are added. The solution is heated 10 minutes at 50° C., then 3 minutes at 75° C. The solution is cooled in a ice bath. The crystals formed are filtered, washed with ethanol. 299 mg of 3-aminocinnamaldehyde thiosemicarbazone is obtained. Yield 68%.
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