Benzyl 3-(3-(methylsulfonamido)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate → N-(3-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)phenyl)methanesulfonamide
反応式
[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[C:8]([CH:37]=[CH:38][CH:39]=1)[CH2:9][N:10]1[C:14](=[O:15])[C:13]2([CH2:20][CH2:19][N:18](C(OCC3C=CC=CC=3)=O)[CH2:17][CH2:16]2)[N:12]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH2:11]1)(=[O:4])=[O:3]>CO.[Pd]>[O:15]=[C:14]1[C:13]2([CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)[N:12]([C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH2:11][N:10]1[CH2:9][C:8]1[CH:7]=[C:6]([NH:5][S:2]([CH3:1])(=[O:4])=[O:3])[CH:39]=[CH:38][CH:37]=1参加物
4
実験手順
To a solution of benzyl 3-(3-(methylsulfonamido)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.82 g, 1.49 mmol) in methanol (15 mL), was added 10 wt % palladium on carbon (0.15 g). After stirring under hydrogen at room temperature and atmospheric pressure for 18 hours, the reaction mixture was filtered, washed with methanol, concentrated in vacuo to obtain N-(3-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)phenyl)methanesulfonamide (0.62 g, 99%).