Ethanol → Dazoquinast

HRID 236319ノート

反応式

HRID 236319 の反応式
[OH-].[Na+].[CH:3]1[N:7]2[C:8]3[C:13]([N:14]=[CH:15][C:6]2=[N:5][C:4]=1[C:16]([O:18]CC)=[O:17])=[CH:12][CH:11]=[CH:10][CH:9]=3.C(O)C>O>[CH:3]1[N:7]2[C:8]3[C:13]([N:14]=[CH:15][C:6]2=[N:5][C:4]=1[C:16]([OH:18])=[O:17])=[CH:12][CH:11]=[CH:10][CH:9]=3

参加物

5

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 13228325Ethyl imidazo[1,2-a]quinoxaline-2-carboxylate

生成物 1

HCID 71146Dazoquinast収率 107.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

10 ml of 1N sodium hydroxide solution were added to a suspension of 0.63 g of ethyl imidazo-[1,2-a]-quinoxaline-2-carboxylate, 10 ml of ethanol and 30 ml of water and the mixture was refluxed for one hour. The ethanol was evaporated under reduced pressure from the resulting clear yellow solution and the aqueous phase was acidified with concentrated hydrochloric acid. The mixture was filtered to obtain 0.6 g of imidazo-[1,2-a]-quinoxaline-2-carboxylic acid in the form of a buff crystalline solid melting at 274°-275° C.

後処理

  1. temperaturethe mixture was refluxed for one hour
  2. customThe ethanol was evaporated under reduced pressure from the resulting clear yellow solution
  3. filtrationThe mixture was filtered

出典と根拠

ORDレコード
ord-e13a3de72d294beabe5c5d2727d101b0
出典データセット
uspto-grants-1987_02
特許番号
US04644002

反応ノート

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