Isopropanol → Isopropyl chloro(oxo)acetate

HRID 2363248ノート

反応式

HRID 2363248 の反応式
[CH:1]([OH:4])([CH3:3])[CH3:2].[C:5](Cl)(=[O:9])[C:6]([Cl:8])=[O:7]>>[CH:1]([O:4][C:5](=[O:9])[C:6]([Cl:8])=[O:7])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 3776IsopropanolHCID 65578Oxalyl chloride

生成物 1

HCID 11355577Isopropyl chloro(oxo)acetate

実験手順

Isopropanol (158 μL, 2.1 mmol, 1.0 eq.) was added dropwise over 5 minutes to oxalyl chloride (350 μL, 4.14 mmol, 2.0 eq.) at 0° C., and the resulting mixture was stirred at room temperature for 2 hours. The excess oxalyl chloride was removed by rotary evaporation (40° C., 50 mmHg) and used without further purification.

後処理

  1. customThe excess oxalyl chloride was removed by rotary evaporation (40° C., 50 mmHg)
  2. customused without further purification

出典と根拠

ORDレコード
ord-cdb7799916274794b599ecc7dc6dbae5
出典データセット
uspto-grants-2014_04
特許番号
US08691868B2

反応ノート

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