Hydrochloric Acid → HCID 13770520、化合物

HRID 236355ノート

反応式

HRID 236355 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([CH:12]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([C:21]3([CH3:26])OCC[O:22]3)[CH:19]=2)[N:14]([CH2:27][CH3:28])[C:13]1=[O:29])=[O:11].O1CCCC1.Cl>O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([CH:12]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([C:21](=[O:22])[CH3:26])[CH:19]=2)[N:14]([CH2:27][CH3:28])[C:13]1=[O:29])=[O:11]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 13770519HCID 13770519、化合物

生成物 1

HCID 13770520HCID 13770520、化合物収率 73%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

N-(2,4-Difluorophenyl)-1-ethyl-5-(2-methyl-4,5-dihydro-1,3-dioxol-2-yl)oxindole-3-carboxamide (636 mg., 1.58 mmoles) was dissolved in 15 ml. of tetrahydrofuran to which was added 10 ml. of 1N hydrochloric acid. The solution was stirred for one hour followed by the addition of an equal volume of water. The resulting precipitate was filtered, vacuum dried and recrystallized from diisopropyl ether--methylene chloride, 412 mg. (73% yield), m.p. 160°-161° C.

後処理

  1. filtrationThe resulting precipitate was filtered
  2. customvacuum dried
  3. customrecrystallized from diisopropyl ether

出典と根拠

ORDレコード
ord-98f5d522817049fe87974001a98463a3
出典データセット
uspto-grants-1987_02
特許番号
US04644005

反応ノート

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