(Piperidine-1-yl)-acetic acid-benzylester → Piperidin-1-yl-acetic acid

HRID 2364932ノート

反応式

HRID 2364932 の反応式
C([O:8][C:9](=[O:17])[CH2:10][N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[N:11]1([CH2:10][C:9]([OH:17])=[O:8])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

参加物

4

反応物 1

HCID 11379293(Piperidine-1-yl)-acetic acid-benzylester

生成物 1

HCID 201097Piperidin-1-yl-acetic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

10.4 g (44 mMol) (piperidine-1-yl)-acetic acid-benzylester 9 was stirred with 0.25 g Pd/C (5%) in 100 ml Methanol at RT. Under normal pressure, the reaction mixture was reduced (hydrated) with H2. After having removed the catalyst, the solution was evaporated and the residue was resuspended in EtOAc and filtered off.

後処理

  1. customAfter having removed the catalyst
  2. customthe solution was evaporated
  3. filtrationfiltered off

出典と根拠

ORDレコード
ord-3c06d4dd3ff941a0b0af65238a7c5a8d
出典データセット
uspto-grants-2014_04
特許番号
US08697604B2

反応ノート

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