[CH2:1]([N:5]1[CH:10]=[CH:9][C:8]([O:11][S:12]([C:15]([F:18])([F:17])[F:16])(=[O:14])=[O:13])=[C:7]([Cl:19])[C:6]1=[O:20])[CH2:2][CH2:3][CH3:4].[CH:21]1(CN2C=CC(O)=CC2=O)CC1.C(N1C=CC(O)=CC1=O)CCC.C(OC1C=CNC(=O)C=1)C1C=CC=CC=1.C1(CBr)CC1>>[Cl:19][C:7]1[C:6](=[O:20])[N:5]([CH2:1][CH2:2][CH:3]([CH3:21])[CH3:4])[CH:10]=[CH:9][C:8]=1[O:11][S:12]([C:15]([F:16])([F:17])[F:18])(=[O:14])=[O:13]Intermediate D6 was prepared following the same procedure implemented for the synthesis of D4, using as starting material 1-cyclopropylmethyl-4-hydroxy-1H-pyridin-2-one which was prepared by the same method used for the synthesis of intermediate D2, by reaction of 4-benzyloxy-1H-pyridin-2-one with cyclopropylmethyl-bromide.
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