dibenzyl N-(N-butanoyl-L-valyl)-L-glutamate → N-(N-butanoyl-L-valyl)-L-glutamic acid

HRID 236499ノート

反応式

HRID 236499 の反応式
[C:1]([NH:6][C@H:7]([C:11]([NH:13][C@H:14]([C:27]([O:29]CC1C=CC=CC=1)=[O:28])[CH2:15][CH2:16][C:17]([O:19]CC1C=CC=CC=1)=[O:18])=[O:12])[CH:8]([CH3:10])[CH3:9])(=[O:5])[CH2:2][CH2:3][CH3:4]>CO.[Pd]>[C:1]([NH:6][C@H:7]([C:11]([NH:13][C@H:14]([C:27]([OH:29])=[O:28])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[O:12])[CH:8]([CH3:9])[CH3:10])(=[O:5])[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 1

HCID 54213157dibenzyl N-(N-butanoyl-L-valyl)-L-glutamate

生成物 1

HCID 53954075N-(N-butanoyl-L-valyl)-L-glutamic acid収率 87.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of dibenzyl N-(N-butanoyl-L-valyl)-L-glutamate (613 mg) and palladium black (50 mg) in methanol (50 ml) was subjected to catalytic hydrogenation under atmospheric pressure. After the reaction mixture was filtered, the filtrate was concentrated under reduced pressure to give a residue which was recrystallized from petroleum ether to afford N-(N-butanoyl-L-valyl)-L-glutamic acid as crystals (343 mg).

後処理

  1. filtrationAfter the reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customto give a residue which
  4. customwas recrystallized from petroleum ether

出典と根拠

ORDレコード
ord-a41bdb0ceab343c782887b6261246620
出典データセット
uspto-grants-1987_02
特許番号
US04643990

反応ノート

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