Ammonia → 4-bromo-1H-indole-2-carboxamide

HRID 2365160ノート

反応式

HRID 2365160 の反応式
C(Cl)(=O)C(Cl)=O.[Br:7][C:8]1[CH:16]=[CH:15][CH:14]=[C:13]2[C:9]=1[CH:10]=[C:11]([C:17]([OH:19])=O)[NH:12]2.[NH3:20]>C(Cl)Cl>[Br:7][C:8]1[CH:16]=[CH:15][CH:14]=[C:13]2[C:9]=1[CH:10]=[C:11]([C:17]([NH2:20])=[O:19])[NH:12]2

参加物

5

反応物 3

HCID 222AmmoniaHCID 65578Oxalyl chlorideHCID 40426044-bromo-1H-indole-2-carboxylic acid

生成物 1

HCID 591512734-bromo-1H-indole-2-carboxamide収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Oxalyl chloride (0.9 mL, 10 mmol) was added to a suspension of 4-bromo-1H-indole-2-carboxylic acid (2.1 g, 8.8 mmol) in DCM and the mixture was stirred for 2 h. The solution formed was added drop-wise to a stirring mixture of ammonia (37%, 50 mL) and ice (50 mL). The resulting mixture was allowed to stand for 3 days. The mixture was filtered and the filtrate extracted with EtOAc. The solid from the filtration was dissolved in EtOAc and the organic solutions were combined, dried (MgSO4) and then evaporated to afford the title compound as a brown solid (2.1 g, 100%).

後処理

  1. customThe solution formed
  2. additionwas added drop-wise
  3. waitto stand for 3 days
  4. filtrationThe mixture was filtered
  5. extractionthe filtrate extracted with EtOAc
  6. filtrationThe solid from the filtration
  7. dissolutionwas dissolved in EtOAc
  8. dry with materialdried (MgSO4)
  9. customevaporated

出典と根拠

ORDレコード
ord-59c60a2e25634da18f36736045ed4cfe
出典データセット
uspto-grants-2014_04
特許番号
US08697693B2

反応ノート

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