Cyclopentylamine → N-(Cyclopentylaminocarbonyl)-2,3-dichlorobenzenesulfonamide

HRID 236519ノート

反応式

HRID 236519 の反応式
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9]([N:12]=[C:13]=[O:14])(=[O:11])=[O:10].[CH:15]1([NH2:20])[CH2:19][CH2:18][CH2:17][CH2:16]1>C(#N)C>[CH:15]1([NH:20][C:13]([NH:12][S:9]([C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([Cl:8])[C:2]=2[Cl:1])(=[O:10])=[O:11])=[O:14])[CH2:19][CH2:18][CH2:17][CH2:16]1

参加物

4

反応物 2

HCID 2906CyclopentylamineHCID 138527082,3-Dichlorobenzenesulfonyl isocyanate

生成物 1

HCID 13852709N-(Cyclopentylaminocarbonyl)-2,3-dichlorobenzenesulfonamide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To 20 mL of the acetonitrile solution containing 2,3-dichlorobenzenesulfonyl isocyanate, prepared as described in the previous example, was added 2.5 mL of cyclopentylamine. This mixture was allowed to sit overnight. The solid precipitate was filtered off and triturated with 5 mL of acetonitrile. Filtration and drying afforded 5.0 g of the title compound as an off-white solid, m.p. 202°-207° C.; NMR (DMSO-d6): δ1.1-1.8 (m, 8H), 3.7 (m, 1H), 6.5 (br d, 1H), 7.6 (t, 1H), 7.9 (dd, 1H), 8.0 (dd, 1H), 10.8 (br s, 1H); IR (nujol): 3343, 1660, 1375, 1170 cm-1.

後処理

  1. customprepared
  2. filtrationThe solid precipitate was filtered off
  3. customtriturated with 5 mL of acetonitrile
  4. filtrationFiltration
  5. customdrying

出典と根拠

ORDレコード
ord-06e6ed168fd14655bebf3edf8d5d11c7
出典データセット
uspto-grants-1987_02
特許番号
US04645527

反応ノート

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