Hydrogen Bromide → 1-(4-Hydroxybenzyl)-1,2,3,6-tetrahydropyridine hydrobromide
反応式
[BrH:1].[OH:2][C:3]1[CH:15]=[CH:14][C:6]([CH2:7][N:8]2[CH2:13][CH:12]=[CH:11][CH2:10][CH2:9]2)=[CH:5][CH:4]=1>CC(C)=O>[BrH:1].[OH:2][C:3]1[CH:15]=[CH:14][C:6]([CH2:7][N:8]2[CH2:9][CH:10]=[CH:11][CH2:12][CH2:13]2)=[CH:5][CH:4]=1参加物
4
実験手順
Aqueous hydrobromic acid (48% w/w) was added dropwise, with stirring, to a solution of 1-(4-hydroxybenzyl)-1,2,3,6-tetrahydropyridine (4.0 g.) in acetone (50 ml.) until no further precipitate was obtained. The solid was collected by filtration and recrystallised from ethanol to give 1-(4-hydroxybenzyl)-1,2,3,6-tetrahydropyridine hydrobromide (Example 18) (2.9 g.), m.p. 187°-190° C.
後処理
- customwas obtained
- filtrationThe solid was collected by filtration
- customrecrystallised from ethanol
出典と根拠
- ORDレコード
- ord-03b8b3cfebe4412193a49d5ec1eff538
- 出典データセット
- uspto-grants-1987_02
- 特許番号
- US04645771
反応ノート
読み込み中…