Sodium Hydroxide → 2-(3-Isopropyl-ureido)-isonicotinic acid
反応式
C([O:3][C:4](=[O:18])[C:5]1[CH:10]=[CH:9][N:8]=[C:7]([NH:11][C:12]([NH:14][CH:15]([CH3:17])[CH3:16])=[O:13])[CH:6]=1)C.[OH-].[Na+]>CO>[CH:15]([NH:14][C:12](=[O:13])[NH:11][C:7]1[CH:6]=[C:5]([CH:10]=[CH:9][N:8]=1)[C:4]([OH:18])=[O:3])([CH3:17])[CH3:16]参加物
4
実験手順
To a solution of 2-(3-Isopropyl-ureido)-isonicotinic acid ethyl ester (130 mg, 0.52 mmol) in MeOH (5 ml) is added 2 M NaOH (2.5 ml) and the resulting solution is stirred for 1.5 hours at room temperature. The solvent is removed in vacuo and sat. aq. NH4Cl solution is added. The pH of the aqueous phase is adjusted to 1 using 1 M HCl and the product extracted into EtOAc, dried (MgSO4) the solvent removed in vacuo to afford 2-(3-Isopropyl-ureido)-isonicotinic acid as a white solid; [M+H]+ 224
後処理
- customThe solvent is removed in vacuo and sat. aq. NH4Cl solution
- additionis added
- extractionthe product extracted into EtOAc
- dry with materialdried (MgSO4) the solvent
- customremoved in vacuo
出典と根拠
- ORDレコード
- ord-e870214c5d864af98bea87b6e32c147f
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08697687B2
反応ノート
読み込み中…