Acetic Acid → 1-(4-Hydroxybenzyl)-1,2,3,6-tetrahydropyridine hydrochloride

HRID 236556ノート

反応式

HRID 236556 の反応式
C([O:9][C:10]1[CH:22]=[CH:21][C:13]([CH2:14][N:15]2[CH2:20][CH:19]=[CH:18][CH2:17][CH2:16]2)=[CH:12][CH:11]=1)(=O)C1C=CC=CC=1.[OH-].[Na+].C(O)(=O)C.[ClH:29]>C(O)C.O>[ClH:29].[OH:9][C:10]1[CH:22]=[CH:21][C:13]([CH2:14][N:15]2[CH2:16][CH:17]=[CH:18][CH2:19][CH2:20]2)=[CH:12][CH:11]=1

参加物

7

反応物 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 202161341-(4-Benzoyloxybenzyl)-1,2,3,6-tetrahydropyridine

生成物 1

HCID 202161261-(4-Hydroxybenzyl)-1,2,3,6-tetrahydropyridine hydrochloride

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A solution of 1-(4-benzoyloxybenzyl)-1,2,3,6-tetrahydropyridine (1.0 g.) in ethanol (15 ml.) and water (5 ml.) containing sodium hydroxide (0.245 g.) was stirred for 2.5 hours. Ice-water (35 ml.) was added followed by acetic acid to pH7. The solid which formed was collected by filtration, washed with water, dried and dissolved in acetone (10 ml.). The solution obtained was acidified with concentrated hydrochloric acid to pH3 to give 1-(4-hydroxybenzyl)-1,2,3,6-tetrahydropyridine hydrochloride (0.6 g.), m.p. 232°-4° C.

後処理

  1. customThe solid which formed
  2. filtrationwas collected by filtration
  3. washwashed with water
  4. customdried
  5. dissolutiondissolved in acetone (10 ml.)
  6. customThe solution obtained

出典と根拠

ORDレコード
ord-1a3e9270cab846bca29f8a7086ed0548
出典データセット
uspto-grants-1987_02
特許番号
US04645771

反応ノート

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