Hydrochloric Acid → Methyl 2-amino-5-chlorobenzoate

HRID 236620

反応式

HRID 236620 の反応式
[ClH:1].[NH2:2][C:3]1[CH:11]=[C:10](Cl)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].[C:13](=O)([O-])[O-].[Na+].[Na+]>CO.O>[NH2:2][C:3]1[CH:11]=[CH:10][C:9]([Cl:1])=[CH:8][C:4]=1[C:5]([O:7][CH3:13])=[O:6]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 666462-Amino-4-chlorobenzoic acid

生成物 1

HCID 78878Methyl 2-amino-5-chlorobenzoate収率 57.3%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A solution of hydrogen chloride (27.1 g) in methanol (192.2 g) is stirred at room temperature and 2-amino-4-chlorobenzoic acid (25 g) is added. The mixture is heated under reflux for 10 hours, then cooled and neutralised with a solution of sodium carbonate (20 g) in water (200 ml). The solid is filtered off, washed with water, and dried in vacuo at 65° C. to give methyl 2-amino-5-chlorobenzoate (15.5 g).

後処理

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 10 hours
  3. temperaturecooled
  4. filtrationThe solid is filtered off
  5. washwashed with water
  6. customdried in vacuo at 65° C.

出典と根拠

ORDレコード
ord-feef69200ce947deb4605e8d75cc6675
出典データセット
uspto-grants-1987_02
特許番号
US04645818

関連ノート

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