Pyridine → Methyl 3-acetyl-4-(2'-isopropoxy-5'-methyl-benzoyloxy)-benzoate

HRID 236700ノート

反応式

HRID 236700 の反応式
[C:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[OH:14])[C:7]([O:9][CH3:10])=[O:8])(=[O:3])[CH3:2].[CH:15]([O:18][C:19]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][C:20]=1[C:21](Cl)=[O:22])([CH3:17])[CH3:16].N1C=CC=CC=1>O1CCOCC1>[C:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[O:14][C:21](=[O:22])[C:20]1[CH:24]=[C:25]([CH3:28])[CH:26]=[CH:27][C:19]=1[O:18][CH:15]([CH3:16])[CH3:17])[C:7]([O:9][CH3:10])=[O:8])(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 1049PyridineHCID 12332833Methyl 3-acetyl-4-hydroxybenzoateHCID 213157482-Isopropoxy-5-methyl-benzoyl chloride

生成物 1

HCID 21315729Methyl 3-acetyl-4-(2'-isopropoxy-5'-methyl-benzoyloxy)-benzoate収率 113.6%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Methyl 3-acetyl-4-hydroxy-benzoate (6 g) in dioxane (100 ml) was reacted with 2-isopropoxy-5-methyl-benzoyl chloride (10 g) in the presence of pyridine (10 ml) at room temperature for 16 hours. After dilution with water, the precipitate was extracted with ethyl acetate and the organic solution was washed with 5% NaHCO3 and water and then evaporated to dryness to give methyl 3-acetyl-4-(2'-isopropoxy-5'-methyl-benzoyloxy)-benzoate (13 g, oil), which was dissolved in methyl-ethyl-ketone (200 ml) and treated with anhydrous potassium carbonate (22 g) under stirring at the reflux temperature for 4 hours.

後処理

  1. extractionAfter dilution with water, the precipitate was extracted with ethyl acetate
  2. washthe organic solution was washed with 5% NaHCO3 and water
  3. customevaporated to dryness

出典と根拠

ORDレコード
ord-0b2b14dab56d4bab94d63009b1de3844
出典データセット
uspto-grants-1979_06
特許番号
US04157334

反応ノート

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