m-Chloroperbenzoic acid → 4-Trifluoromethyl-2-picoline-N-oxide
反応式
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][N:3]=1.ClC1C=CC=C(C(OO)=[O:20])C=1>C(Cl)Cl>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]([F:9])([F:11])[F:10])[CH:5]=[CH:4][N+:3]=1[O-:20]参加物
4
実験手順
To a solution of 2-methyl-4-(trifluoromethyl)pyridine (3.9 g, 24 mmol) in methylene chloride (50 mL) was added m-chloroperbenzoic acid (7.0 g, 31 mmol). After being stirred at room temperature overnight, the solution was washed with 50 mL of 1 N NaOH. The water phase was back-extracted with methylene chloride. The combined organic phases were dried over Na2SO4 and concentrated under vacuum to give the title compound. MS (M+H) 178.1.
後処理
- washthe solution was washed with 50 mL of 1 N NaOH
- extractionThe water phase was back-extracted with methylene chloride
- dry with materialThe combined organic phases were dried over Na2SO4
- concentrationconcentrated under vacuum
出典と根拠
- ORDレコード
- ord-33c08edb63534707adbdee9c3bc9cc57
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08697870B2
反応ノート
読み込み中…