Sodium Hydroxide → 2-(Hydroxymethyl)-4-(trifluoromethyl)pyridine
反応式
C([O:4][CH2:5][C:6]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[CH:8][N:7]=1)(=O)C.[OH-].[Na+]>CO.O>[F:14][C:12]([F:13])([F:15])[C:10]1[CH:9]=[CH:8][N:7]=[C:6]([CH2:5][OH:4])[CH:11]=1参加物
5
実験手順
To a solution of [4-(trifluoromethyl)pyridin-2-yl]methyl acetate (1.0 g, 3.2 mmol) in methanol (10 mL) was added a 1.0 M solution of sodium hydroxide in water (10 mL). After being stirred at room temperature overnight, the solution was diluted with 20 mL of water and extracted with EtOAc twice. The combined organic layers were dried (MgSO4) and concentrated under vacuum. Chromatography on silica gel eluting with hexanes/EtOAc (1:1) afforded the title compound (0.34 g) as a clear oil. MS (M+H) 178.1.
後処理
- extractionextracted with EtOAc twice
- dry with materialThe combined organic layers were dried (MgSO4)
- concentrationconcentrated under vacuum
出典と根拠
- ORDレコード
- ord-951ac8b146774bb5ae5fd65d9d13fcd3
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08697870B2
反応ノート
読み込み中…