Hydrochloric Acid → HCID 178477956、化合物

HRID 2367337ノート

反応式

HRID 2367337 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH:13]3[O:18][CH2:17][CH2:16][N:15](CC4C=CC=CC=4)[CH2:14]3)[NH:11][CH:12]=2)=[CH:4][CH:3]=1.Cl>C(O)C.[Pd]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH:13]3[O:18][CH2:17][CH2:16][NH:15][CH2:14]3)[NH:11][CH:12]=2)=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 1784779552-[4-(4-Chlorophenyl)-1H-imidazol-2-yl]-4-(phenylmethyl)morpholine

生成物 1

HCID 178477956HCID 178477956、化合物収率 139%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

2-[4-(4-Chlorophenyl)-1H-imidazol-2-yl]-4-(phenylmethyl)morpholine (2.8 g, 7.91 mmol) was hydrogenated in ethanol (30 mL) over of Pd/C (10 wt %, 0.842 g, 0.791 mmol). To the mixture 0.2 mL of concentrated hydrochloric acid was added. After stirred at room temperature overnight, the catalyst was filtered off. The filtrate was concentrated to get 2.9 g of residue, which was purified by preparative HPLC to afford the title compound (200 mg) as a pale solid. LC-MS (ES) m/z=264 [M+H]+.

後処理

  1. filtrationthe catalyst was filtered off
  2. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-cc4ed663ce224a338ea6082eea4c08c9
出典データセット
uspto-grants-2014_04
特許番号
US08697685B2

反応ノート

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