Hydrochloric Acid → 2-(2-Morpholinyl)-4,5,6,7-tetrahydro-1H-benzimidazole

HRID 2367344ノート

反応式

HRID 2367344 の反応式
C1(C[N:8]2[CH2:13][CH2:12][O:11][CH:10]([C:14]3[NH:18][C:17]4[CH2:19][CH2:20][CH2:21][CH2:22][C:16]=4[N:15]=3)[CH2:9]2)C=CC=CC=1.Cl>C(O)C.[Pd]>[NH:8]1[CH2:13][CH2:12][O:11][CH:10]([C:14]2[NH:15][C:16]3[CH2:22][CH2:21][CH2:20][CH2:19][C:17]=3[N:18]=2)[CH2:9]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 585048062-[4-(Phenylmethyl)-2-morpholinyl]-4,5,6,7-tetrahydro-1H-benzimidazole

生成物 1

HCID 585044142-(2-Morpholinyl)-4,5,6,7-tetrahydro-1H-benzimidazole収率 147.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

2-[4-(Phenylmethyl)-2-morpholinyl]-4,5,6,7-tetrahydro-1H-benzimidazole (0.78 g, 2.62 mmol) was hydrogenated in ethanol (30 mL) in the presence of Pd/C (10 wt %, 0.279 g, 0.262 mmol). To the reaction mixture was added 0.2 mL of concentrated hydrochloric acid. After stirring at room temperature overnight, the catalyst was filtered off. The filtrate was concentrated to afford the title compound (0.8 g) as a yellow oil. LC-MS (ES) m/z=208 [M+H]+.

後処理

  1. filtrationthe catalyst was filtered off
  2. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-49179edbbc5e499aaebf2cf1e331f81e
出典データセット
uspto-grants-2014_04
特許番号
US08697685B2

反応ノート

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