Hydrochloric Acid → 2-Amino-4'-methoxyacetophenone
反応式
[N:1]([CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1)=[O:6])=[N+]=[N-].[ClH:15]>[Pd].CO>[ClH:15].[NH2:1][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1)=[O:6]参加物
6
反応条件
- 温度
- 25 °C
実験手順
Palladium on carbon (10 wt %, 1.67 g, 1.57 mmol) was added to a solution of 2-azido-1-[4-(methyloxy)phenyl]ethanone (3.0 g, 15.69 mmol) and hydrochloric acid (6.62 mL, 78 mmol) in CH3OH (90 mL) under nitrogen, and the reaction mixture was stirred under hydrogen overnight at 25° C. The mixture was filtered, washed by EtOAc (150 mL), and concentrated to afford an HCl salt of the title compound (3.0 g) as a yellow solid. LC-MS (ES) m/z=166 [M+H]+.
後処理
- filtrationThe mixture was filtered
- washwashed by EtOAc (150 mL)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-802e1c3052a143bb97e2001e58e30178
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08697685B2
反応ノート
読み込み中…