(2S,5R)-5-Ethyl-4-(phenylmethyl)-2-morpholinemethanol → [(2S,5R)-5-Ethylmorpholin-2-yl]methanol

HRID 2367550ノート

反応式

HRID 2367550 の反応式
[CH2:1]([C@H:3]1[N:8](CC2C=CC=CC=2)[CH2:7][C@@H:6]([CH2:16][OH:17])[O:5][CH2:4]1)[CH3:2]>CO.[Pd]>[CH2:1]([C@H:3]1[NH:8][CH2:7][C@@H:6]([CH2:16][OH:17])[O:5][CH2:4]1)[CH3:2]

参加物

4

反応物 1

HCID 51357958(2S,5R)-5-Ethyl-4-(phenylmethyl)-2-morpholinemethanol

生成物 1

HCID 51354034[(2S,5R)-5-Ethylmorpholin-2-yl]methanol収率 100.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

[(2S,5R)-5-Ethyl-4-(phenylmethyl)-2-morpholinyl]methanol (0.5 g, 2.125 mmol) was dissolved in CH3OH (20 mL) and placed under a nitrogen atmosphere. Palladium on carbon (10 wt %, 0.023 g, 0.212 mmol) was added and the flask was flushed with nitrogen and evacuated (3×). Then the reaction was placed under an atmosphere of hydrogen (balloon), and stirred at room temperature overnight. The reaction mixture was filtered through celite and concentrated to afford the title compound (0.309 g) as a colorless oil. LC-MS (ES) m/z=146 [M+H]+.

後処理

  1. customthe flask was flushed with nitrogen
  2. customevacuated (3×)
  3. filtrationThe reaction mixture was filtered through celite
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-12226534b9bb46bcaacad048d0fab5b6
出典データセット
uspto-grants-2014_04
特許番号
US08697685B2

反応ノート

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