化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 3-Dimethylamino-2-phenyl-benzo(b)thiophene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | Dimethylazanide | HCID 182180 | — |
| 反応物 | 2-Phenyl-2-(phenylsulfanyl)acetic acid | HCID 239605 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 3-Dimethylamino-2-phenyl-benzo(b)thiophene | HCID 15700632 | — |
反応手順
A solution of 14.4 g (53 mmole) of the dimethylamide of α-phenylthio-phenylacetic acid, 24.5 milliliters (160 mmole) of POCl3 in 250 milliliters of absolute toluene is refluxed for 6 hours. After mixing with water, it is neutralised with ammonia and the organic phase is dried over a mixture of K2CO3 and activated charcoal and evaporated: 3-dimethylamino-2-phenyl-benzo(b)thiophene in the form of a crude oily produce which, triturated with methanol, yields 11.1 g (83% of theory) of colourless rods, mp 84°-85° (methanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04157399 |
| 出典データセット | uspto-grants-1979_06 |
| ORD ID | ord-1b16b0e5f0904b9b8d91e26e2c795c58 |
| 出典メモ | uspto-grants-1979_06 |