Bromomethylcyclopropane → HCID 70097090、化合物
反応式
[CH2:1]([O:3][C:4]([C:6]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][NH:8][N:7]=1)=[O:5])[CH3:2].Br[CH2:15][CH:16]1[CH2:18][CH2:17]1>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH2:15][CH:16]2[CH2:18][CH2:17]2)[N:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])=[O:5])[CH3:2]参加物
3
実験手順
The product was obtained according to the method described in example 4, step 2 starting from 4-nitro-1H-pyrazole-3-carboxylic acid ethyl ester and bromomethyl-cyclopropane as a mixture of regioisomers which were separated by silica gel chromatography using a heptane/ethyl acetate gradient to yield 179 mg (46%) of the desired regioisomer and 88 mg (23%) of 2-cyclopropylmethyl-4-nitro-2H-pyrazole-3-carboxylic acid ethyl ester.
後処理
- customThe product was obtained
- customwere separated by silica gel chromatography
出典と根拠
- ORDレコード
- ord-818383f8ba8e435984bb12f9fe2cdf6d
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08703768B2
反応ノート
読み込み中…