Diisobutylaluminumhydride → 1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carbaldehyde

HRID 2368492ノート

反応式

HRID 2368492 の反応式
FC1C=CC(N2C(C=O)=CN=C2S)=CC=1.[F:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]2[C:27]([C:28](N(OC)C)=[O:29])=[CH:26][N:25]=[C:24]2[S:34][CH2:35][C:36]2[C:41]([F:42])=[CH:40][CH:39]=[C:38]([F:43])[C:37]=2[F:44])=[CH:19][CH:18]=1.[H-].C([Al+]CC(C)C)C(C)C>C1COCC1>[F:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]2[C:27]([CH:28]=[O:29])=[CH:26][N:25]=[C:24]2[S:34][CH2:35][C:36]2[C:41]([F:42])=[CH:40][CH:39]=[C:38]([F:43])[C:37]=2[F:44])=[CH:19][CH:18]=1

参加物

5

反応物 3

HCID 21225700DiisobutylaluminumhydrideHCID 866775411-(4-Fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamideHCID 178519842HCID 178519842、化合物

生成物 1

HCID 866775501-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carbaldehyde

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carbaldehyde (32) was prepared in a similar manner as that described for the synthesis of compound 12 using 1-(4-fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide (9) (1.15 g, 2.7 mmol), diisobutyl aluminum hydride (DiBAL) (1M in THF, 5.5 mL, 5.5 mmol), and THF (5 mL).

出典と根拠

ORDレコード
ord-df16d8664b4e4316a70296a325a119d4
出典データセット
uspto-grants-2014_04
特許番号
US08703776B2

反応ノート

読み込み中…