N-(4-Bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-5-nitro-nicotinamide → 5-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide

HRID 2368663ノート

反応式

HRID 2368663 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:26])[C:10]2[CH:15]=[C:14]([N+:16]([O-])=O)[C:13]([NH:19][CH3:20])=[N:12][C:11]=2[O:21][CH2:22][CH:23]([F:25])[F:24])=[CH:4][CH:3]=1>[Ni].C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:26])[C:10]2[CH:15]=[C:14]([NH2:16])[C:13]([NH:19][CH3:20])=[N:12][C:11]=2[O:21][CH2:22][CH:23]([F:24])[F:25])=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 86664893N-(4-Bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-5-nitro-nicotinamide

生成物 1

HCID 866648925-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8028Tetrahydrofuran溶媒

実験手順

Prepared analogously to example 154d by hydrogenation of the product obtained in (771f) using Raney nickel in THF.

後処理

  1. customPrepared analogously to example 154d by hydrogenation of the product

出典と根拠

ORDレコード
ord-543ae5d2267346549c3773248a77fe4b
出典データセット
uspto-grants-2014_04
特許番号
US08703796B2

反応ノート

読み込み中…