Thionyl Chloride → HCID 67456441、化合物

HRID 2368765

反応式

HRID 2368765 の反応式
O[CH:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]#[N:12])=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.S(Cl)([Cl:15])=O>C(Cl)Cl>[Cl:15][CH:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]#[N:12])=[CH:8][CH:9]=2)[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 145153231-hydroxy-2,3-dihydro-1H-indene-5-carbonitrile

生成物 1

HCID 67456441HCID 67456441、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1-Hydroxy-2,3-dihydro-1H-indene-5-carbonitrile (4.77 g, 30 mmol) was dissolved in 10 mL of methylene dichloride. While cooled on ice, thionyl chloride (6.6 ml, 90 mmol) was added dropwise within about 15 minutes. The solution was concentrated after being stirred for 3 hours. The residue was dissolved in ethyl acetate and the solution obtained was washed with cooled brine for 3 times, dried over anhydrous magnesium sulfate, and concentrated to obtain 1-chloro-2,3-dihydro-1H-indene-5-carbonitrile.

後処理

  1. additionwas added dropwise within about 15 minutes
  2. concentrationThe solution was concentrated
  3. dissolutionThe residue was dissolved in ethyl acetate
  4. customthe solution obtained
  5. washwas washed with cooled brine for 3 times
  6. dry with materialdried over anhydrous magnesium sulfate
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-1bceab36026f4f35a34eaa2018214aca
出典データセット
uspto-grants-2014_04
特許番号
US08703771B2

関連ノート

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