Benzaldehyde → 4-(2-Phenylethenyl)pyridine

HRID 236881

反応式

HRID 236881 の反応式
[NH+:1]1[CH:6]=[CH:5][C:4]([CH3:7])=[CH:3][CH:2]=1.[CH:8](=O)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.N1CCCCC1.[OH-].[Na+]>C(O)(C)C>[CH:7]([C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1)=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

参加物

6

反応物 4

HCID 240BenzaldehydeHCID 8082PiperidineHCID 14798Sodium HydroxideHCID 34343784-Methylpyridinium

生成物 1

HCID 1015764-(2-Phenylethenyl)pyridine

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

To 67.5 parts of the 4-picolinium quaternary salt as in Example 13 but without the acid salt was added 100 parts isopropanol, 32.5 parts benzaldehyde, and one part piperidine. The resulting solution was boiled at reflux two hours, 100 parts 40% sodium hydroxide added, and the heating continued for two hours. The cooled mixture was extracted with chloroform, and the organic phase evaporated to dryness to yield a residue that was recrystallized from methanol-water to give 21 parts 4-styrylpyridine.

後処理

  1. temperatureat reflux two hours
  2. extractionThe cooled mixture was extracted with chloroform
  3. customthe organic phase evaporated to dryness
  4. customto yield a residue that
  5. customwas recrystallized from methanol-water

出典と根拠

ORDレコード
ord-34760d1e90e14ea3aa3e2fc44893f46d
出典データセット
uspto-grants-1979_06
特許番号
US04158093

関連ノート

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