Water → 2-(2-Fluoro-3-methoxyphenyl)acetic acid

HRID 2368932ノート

反応式

HRID 2368932 の反応式
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:10][C:11]#N.[OH-:13].[Na+].[OH2:15]>CO>[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:10][C:11]([OH:15])=[O:13]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 230744722-(2-Fluoro-3-methoxyphenyl)acetonitrile

生成物 1

HCID 230744162-(2-Fluoro-3-methoxyphenyl)acetic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

To a mixture of 2-(2-fluoro-3-methoxyphenyl)acetonitrile (6.7 g, 40.6 mmol) in water (40 mL) and methanol (40 mL), sodium hydroxide (3.2 g, 81.1 mmol) was added. The resulting mixture was stirred at 60° C. for 5 h. After cooling to room temperature, methanol was evaporated under reduced pressure. The residue was acidified with 10% HCl until pH 5. The resulting precipitate was collected by filtration and dried to afford the title compound (6.3 g).

後処理

  1. additionwas added
  2. temperatureAfter cooling to room temperature
  3. custommethanol was evaporated under reduced pressure
  4. filtrationThe resulting precipitate was collected by filtration
  5. customdried

出典と根拠

ORDレコード
ord-39e5d5cd4832495c8da6ba6a6315240a
出典データセット
uspto-grants-2014_04
特許番号
US08703810B2

反応ノート

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