Tert-butyl 7-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate → 5-(3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3-(6-phenylpyridin-3-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one

HRID 2369004ノート

反応式

HRID 2369004 の反応式
C[Si](C)(C)CCOC[N:7]([CH2:50]OCC[Si](C)(C)C)[C:8]1[N:13]2[N:14]=[CH:15][C:16]([C:17]3[CH:18]=[N:19][C:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)=[CH:21][CH:22]=3)=[C:12]2[N:11]=[C:10]([CH:29]2[CH2:36][CH:35]3[N:37](C(OC(C)(C)C)=O)[CH:31]([CH2:32][O:33][CH2:34]3)[CH2:30]2)[C:9]=1[C:45]([O:47]CC)=[CH2:46]>C(O)(C(F)(F)F)=O>[CH:31]12[NH:37][CH:35]([CH2:36][CH:29]([C:10]3[C:9]4[C:45](=[O:47])[CH2:46][CH2:50][NH:7][C:8]=4[N:13]4[N:14]=[CH:15][C:16]([C:17]5[CH:18]=[N:19][C:20]([C:23]6[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=6)=[CH:21][CH:22]=5)=[C:12]4[N:11]=3)[CH2:30]1)[CH2:34][O:33][CH2:32]2

参加物

3

反応物 1

HCID 86686739Tert-butyl 7-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate

生成物 1

HCID 1364047575-(3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3-(6-phenylpyridin-3-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

tert-butyl 7-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate was treated with anhydrous TFA (10 mL) at rt and the mixture was stirred for 16 h. Then the solvent was evaporated off under reduced pressure and the material was lyophilized from acetonitrile:water (3:1) to give compound 5-(3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3-(6-phenylpyridin-3-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one as yellow solid (122 mg) which was used without further purification. HPLC-MS tR=1.16 min (UV254 nm). Mass calculated for formula C26H26N6O2 454.2; observed MH+ (LCMS) 455.2 (m/z).

後処理

  1. customThen the solvent was evaporated off under reduced pressure

出典と根拠

ORDレコード
ord-978f11d1f97d4c2fbdcdf9aae72822ae
出典データセット
uspto-grants-2014_04
特許番号
US08703784B2

反応ノート

読み込み中…