Sodium borohydride → N-[4-(2-bromo-1-hydroxyethyl)phenyl]acetamide

HRID 23693

反応式

HRID 23693 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][CH:6]=1)=[O:4].[BH4-].[Na+]>C(OCC)C.O>[Br:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][CH:6]=1)[OH:4]

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 12364739N-[4-(2-Bromoacetyl)Phenyl]Acetamide

生成物 1

HCID 22563212N-[4-(2-bromo-1-hydroxyethyl)phenyl]acetamide収率 18.9%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

To a solution of N-[4-(2-bromoacetyl)phenyl]acetamide (2.1 g, 0.0082 mol, in 30 mL of methanol) was introduced solid NaBH4 (1.0 g, 0.026 mol) at 0° C. and stirred at that temperature for 15 minutes. The mixture was diluted with diethyl ether (20 mL) and water (20 mL). The ether phase was separated and the aqueous phase was extracted with diethyl ether. The ether phases were combined and washed with brine, dried. Purification on a silica gel column gave the title compound as a white solid (0.40 g).

後処理

  1. customThe ether phase was separated
  2. extractionthe aqueous phase was extracted with diethyl ether
  3. washwashed with brine
  4. customdried
  5. customPurification on a silica gel column

出典と根拠

ORDレコード
ord-8ad6315898104647b2eb53bf2349ec6b
出典データセット
uspto-grants-2005_02
特許番号
US06852731B2

関連ノート

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