17-{3-[(2-Benzyloxycarbonylethyl)tert-butoxycarbonylamino]propionylamino}heptadecanoic acid tert-butyl ester → 17-{3-[tert-Butoxycarbonyl (2-carboxyethyl)amino]propionylamino}heptadecanoic acid tert-butyl ester

HRID 2369796ノート

反応式

HRID 2369796 の反応式
[C:1]([O:5][C:6](=[O:48])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][NH:23][C:24](=[O:47])[CH2:25][CH2:26][N:27]([CH2:35][CH2:36][C:37]([O:39]CC1C=CC=CC=1)=[O:38])[C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])([CH3:4])([CH3:3])[CH3:2]>C1COCC1>[C:1]([O:5][C:6](=[O:48])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][NH:23][C:24](=[O:47])[CH2:25][CH2:26][N:27]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:35][CH2:36][C:37]([OH:39])=[O:38])([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 1

HCID 6876904917-{3-[(2-Benzyloxycarbonylethyl)tert-butoxycarbonylamino]propionylamino}heptadecanoic acid tert-butyl ester

生成物 1

HCID 8664713017-{3-[tert-Butoxycarbonyl (2-carboxyethyl)amino]propionylamino}heptadecanoic acid tert-butyl ester収率 102.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

17-{3-[(2-Benzyloxycarbonylethyl)tert-butoxycarbonylamino]propionylamino}heptadecanoic acid tert-butyl ester (0.135 g, 0.2 mmol) was dissolved in THF (10 mL) in a flask. The flask was filled with nitrogen and purged under vacuum several times. Pd/C, wet 10% (0.03 g) was added and the flask was equipped with a balloon filled with the mixture was stirred for 16 h. The mixture was filtered through a celite, eluting with THF. The filtrate was concentrated under vacuum. TLC indicated the reaction was not complete, so the process was repeated twice more. The filtrate was concentrated under vacuum to yield a yellow oil (0.12 g)

後処理

  1. additionThe flask was filled with nitrogen
  2. custompurged under vacuum several times
  3. additionPd/C, wet 10% (0.03 g) was added
  4. customthe flask was equipped with a balloon
  5. additionfilled with the mixture
  6. filtrationThe mixture was filtered through a celite
  7. washeluting with THF
  8. concentrationThe filtrate was concentrated under vacuum
  9. concentrationThe filtrate was concentrated under vacuum

出典と根拠

ORDレコード
ord-a56a7a4af1394f78af270315569bf34c
出典データセット
uspto-grants-2014_04
特許番号
US08710000B2

反応ノート

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