Formamide → HCID 20277966、化合物
反応式
Br[CH:2]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)[C:3]([C:5]1[S:6][CH:7]=[CH:8][CH:9]=1)=O.[CH:17]([NH2:19])=O.O.[OH-].[NH4+:22]>C(Cl)(Cl)Cl>[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C:2]2[N:22]=[CH:17][NH:19][C:3]=2[C:5]2[S:6][CH:7]=[CH:8][CH:9]=2)=[CH:11][CH:12]=1参加物
6
実験手順
A mixture of 35 g of 2-bromo-2-(4-chlorophenyl)-1-(2-thienyl)ethanone and 200 ml of formamide was refluxed under an air condenser for two hours. It was cooled, poured into water and the pH adjusted to 8-9 by adding ammonium hydroxide. Chloroform was added to the solution, and solid separated and was filtered and washed with chloroform; yield 19.3 g. This was recrystallized from dimethylformamide, filtered and washed with acetonitrile; yield 14.7 g, m.p. 244°-245° C.
後処理
- temperaturewas refluxed under an air condenser for two hours
- temperatureIt was cooled
- customseparated
- filtrationwas filtered
- washwashed with chloroform
- customThis was recrystallized from dimethylformamide
- filtrationfiltered
- washwashed with acetonitrile
出典と根拠
- ORDレコード
- ord-5f0bc647402b411d9a467987d806ffe4
- 出典データセット
- uspto-grants-1979_06
- 特許番号
- US04159338
反応ノート
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