Water → Ethanone, 2-hydroxy-2-phenyl-1-(3-pyridinyl)-

HRID 237007ノート

反応式

HRID 237007 の反応式
Br.Br[CH:3]([C:10]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C([O-])(=[O:20])C.[K+].O>C(OC(=O)C)(=O)C>[OH:20][CH:3]([C:10]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 962WaterHCID 517044Potassium AcetateHCID 134660052-Bromo-2-phenyl-1-(3-pyridyl)ethanone hydrobromide

生成物 1

HCID 20460416Ethanone, 2-hydroxy-2-phenyl-1-(3-pyridinyl)-収率 68.3%

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

Alternatively, a mixture of 20.0 g (56.0 mmoles) of 3-pyridyl α-bromobenzyl ketone hydrobromide and 24.0 g (0.24 mole) of potassium acetate in 100 ml of acetic anhydride was stirred overnight at room temperature. The reaction mixture was poured into water and the product extracted into ether. The combined ether layers were washed with water and then 10% aqueous sodium bicarbonate solution. The ether layer was dried over potassium carbonate and evaporated. A solution of the residue in 140 ml of 1 N aqueous hydrochloric acid was heated at reflux for 30 minutes and after cooling made basic with solid sodium carbonate. The product was extracted into ether and the combined ether extracts evaporated, after drying over anhydrous potassium carbonate, to give 8.15 g of 3-pyridyl α-hydroxybenzyl ketone.

後処理

  1. extractionthe product extracted into ether
  2. washThe combined ether layers were washed with water
  3. dry with materialThe ether layer was dried over potassium carbonate
  4. customevaporated
  5. temperatureA solution of the residue in 140 ml of 1 N aqueous hydrochloric acid was heated
  6. temperatureat reflux for 30 minutes
  7. temperatureafter cooling
  8. extractionThe product was extracted into ether
  9. customthe combined ether extracts evaporated
  10. dry with materialafter drying over anhydrous potassium carbonate

出典と根拠

ORDレコード
ord-1ccac70cca1c495e93f97daeeddfa1a3
出典データセット
uspto-grants-1979_06
特許番号
US04159338

反応ノート

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