HCID 766883、化合物 → 4-[[4-(2-Pyridinyl)-1-piperazinyl]sulfonyl]benzenamine

HRID 237023ノート

反応式

HRID 237023 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)[CH2:15][CH2:14]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-])=O.[H][H]>[Pd].C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)[CH2:15][CH2:14]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1

参加物

5

反応物 2

HCID 766883HCID 766883、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 213149164-[[4-(2-Pyridinyl)-1-piperazinyl]sulfonyl]benzenamine収率 81.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 10.62 g (0.0305 m) of 1-[(p-nitrophenyl)sulfonyl]-4-(2-pyridinyl)piperazine, 1.5 g of 5% palladium on charcoal, and 150 ml of absolute ethanol is shaken under hydrogen on a Parr hydrogenator. After the theoretical amount of hydrogen has been taken up, the catalyst is filtered off and the filtrate is taken to dryness. The product, 1-[(p-aminophenyl)sulfonyl]-4-(2-pyridinyl)piperazine, is crystallized from methanol/methylene chloride to give 7.89 g (81%) of 1-[(p-aminophenyl)sulfonyl]-4-(2-pyridinyl)piperazine of melting point 208°-210° C.

後処理

  1. filtrationthe catalyst is filtered off
  2. customThe product, 1-[(p-aminophenyl)sulfonyl]-4-(2-pyridinyl)piperazine, is crystallized from methanol/methylene chloride

出典と根拠

ORDレコード
ord-0cb10a9ccff14731aadb60a726908d6d
出典データセット
uspto-grants-1979_06
特許番号
US04159331

反応ノート

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